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BMP-2 Human Recombinant Protein

BMP-2 Human Recombinant Protein

Regular price $125.00
Regular price Sale price $125.00
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Product Description

Bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor beta (TGF-β) superfamily of proteins. It plays a crucial role in the development and maintenance of bone and cartilage. BMP-2 is involved in various cellular processes, including cell differentiation, proliferation, and apoptosis.

Our products are produced using a proprietary plant based expressed system.

  • Animal Component Free (ACF). No endotoxins, prions or virons to risk microbial contamination
  • Highly flexible platform used to produce multiple proteins with minimal changes to method
  • Our proteins generally have 10% to 20% higher activity

Price Match Guarantee

If you find a lower price of BMP-2 recombinant protein, send us a copy of the estimate or a link to the online listing and we'll match the price for quantity. It's that EASY! Send to orders@mnpharm.com.

Current Lead Time

1-2 Working Days 

Product Specifications

Species
Human*
Expression System Nicotiana Benthamiana
Purity >95% by SDS-PAGE
Activity
0.3-3.75 ng/mL EC50
Activity Assay Induced HUVEC proliferation assay data
Cell proliferation is measured by Rezasurin
rhVEGF165 MNPHARM, ED50 = 4.557 ng/mL
Using 2 mg/mL concentration measurement
Animal Component Free (ACF) Yes
Molecular Weight
25 kDa
Structure Disulfide-linked homodimer
Endotoxin Concentration
<1 EU/µg
Purification Sequential Chromatography
Form
Frozen
Formulation Supplied as a 0.22 µm filtered solution, 50 mM MES, 10% glycerol, pH 5

*For Research Use Only

Sequence

MQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

MNPharm Guarantee

If your product BMP-2 is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instructions

Reconstituted store at -20°C or -80°C.
We recommend that single use aliquots are prepared to avoid freeze-thaw cycles."

Sample Prep Instructions 

  1. Thaw the vial on ice, spin briefly
  2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
  3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
  4. We recommend sterile filtering after dilution in media or the final working solution

Bioinformatics

Alternative Names: 

UniProt ID: (Human) P12643

Entrez Gene ID: (Human) 55589

 

Documents & Downloads

      


References

  1. Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model. Tissue Eng 2006 Nov;12(11):3181-8
  2. Skull bone regeneration in nonhuman primates by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel. Tissue Eng 2007 Feb;13(2):293-300
  3. The in vivo biological effects of intradiscal recombinant human bone morphogenetic protein-2 on the injured intervertebral disc: an animal experiment. Spine 2007 May 15;32(11):1174-80
  4. The effect of recombinant human bone morphogenetic protein-2 on the osteogenic potential of rat mesenchymal stem cells after several passages. Acta Orthop 2007 Apr;78(2):285-92
  5. Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development. Immunology 2007 May;121(1):94-104
  6. Re: Dimar JR, Glassman SD, Burkus KJ, et al. Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft. Spine 2006; 31:2534-40. Spine 2007 Mar 15;32(6):708; author reply 708 

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